If you wrote off amp simulators in the past, take another look. A major complaint about these sims in the past was latency. Many simulators now have multiple options, including a low-latency mode for playing live. If you do decide to try out an amp simulator, be sure to look carefully at the numerous settings available to tweak.
You can read more here: http://en.audiofanzine.com/music-software/editorial/articles/amp-simulators-tips-you-need-to-know.html
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